2018년 4월 18일 Molecules and Cells (IF: 3.054)에 시냅스 특이성 (synaptic specificity)에 관여하는 주요 분자기전 관련 연구결과들을 정리한 종설논문이 online 게재되었습니다.
2018 Apr 18. doi: 10.14348/molcells.2018.0081. [Epub ahead of print]
Molecular Mechanisms of Synaptic Specificity: Spotlight on Hippocampal and Cerebellar Synapse Organizers.
Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present minireview, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum.